Thiolated Chitosan: A Boon to Ocular Delivery of Therapeutics
نویسندگان
چکیده
منابع مشابه
Thiolated Chitosan: A Boon to Ocular Delivery of Therapeutics
Despite numerous scientific efforts many challenges need to be overcome in the ocular delivery because eyes have special and complex anatomic structures. The main problem with the conventional dosage forms is poor ocular bioavailability due to minimum ocular residence time, because of various anatomical and pathophysiological barriers prevailing in the eye. For this reason, much effort has been...
متن کاملSynthesis of thiolated chitosan and preparation nanoparticles with sodium alginate for ocular drug delivery
PURPOSE The goal of the present study was to synthesize mucoadhesive polymer - thiolated chitosan (TCS) from chitosan (CS), then prepared CS/TCS-sodium alginate nanoparticles (CS/TCS-SA NPs), determined which was more potential for ocular drug delivery. METHODS A new method for preparing TCS was developed, and the characteristics were determined using Fourier transform infrared spectroscopy a...
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Chitosan has been widely used as a key biomaterial for the development of drug delivery systems intended to be administered via oral and parenteral routes. In particular, chitosan-based microparticles are the most frequently employed delivery system, along with specialized systems such as hydrogels, nanoparticles and thin films. Based on the progress made in chitosan-based drug delivery systems...
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Carbon nanotubes (CNTs) are high aspect ratio allotropes of carbon. Because of their unique physical and chemical characteristics, they are nominated for a vast variety of applications in the biomedical field. Their very low solubility is the only problem of them which is solved by different methods of Functionalization. After discoveries in the last few years of the capacity of CNTs to penetra...
متن کاملFunctionalized CNTs for delivery of therapeutics
Carbon nanotubes (CNTs) are high aspect ratio allotropes of carbon. Because of their unique physical and chemical characteristics, they are nominated for a vast variety of applications in the biomedical field. Their very low solubility is the only problem of them which is solved by different methods of Functionalization. After discoveries in the last few years of the capacity of CNTs to penetra...
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ژورنال
عنوان ژورنال: MOJ Bioequivalence & Bioavailability
سال: 2017
ISSN: 2573-2951
DOI: 10.15406/mojbb.2017.03.00029